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WHAT IS LIFE WHENCE CAME IT By John Butler Burtte Professor at Cavendish Laboratory Cam bridge, England sy.yk a-'- .ma -w.aTanB. i " i w ci S-A.) WPtrasHsflflt tcTsBsBBSi IVBsHsB7 kLDnHsBHvK yijSJSSjSjM7Hy-5a)y An Explanation of His Itecent Experiments With Radium :-X TUB experiments in which I have been engaged have aroused so much public interest, and have caused so many suggestions. criticisms guarded and unguarded, whether friendly or other wise, that I am now, however reluctantly. co:n IH'lIcd to sjwak. Primarily. I want to Ktint out the great danger there i of a preliminary scientific note in a scientific journal taing misunderstood to some extent, as I fear it li.fi lccn. and perhaps also misconstrued by the cnthub.ia.stic mind of the public. The question as to whether the microscopic forms which I have obtained with sterilized tauillon the ordinary culture medium and radium are or are not living things dejiends altogether ujon what our conception of life is. and ujm how broad or how narrow is the definition we are willing to accept of the phenoma of vital processes. When these atoms which I have obtained are examined through a microscojie a distinct indication of growth and segregation is seen. They reach a certain size and" then divide. That would indicate clearly that they are not crystals. They are ossihy a primitive form of life. Everything, or nearly so. is radio active the earth is. and in some suitable medium life may have originated on the earth in such a manner. The professed biologist, as it seems (I ilo not profess to lc ont!. since physics is the subject to which I have been particularly devoted) should have the right to sjieak and to decide for us the question as to what is to lie understood by living ami not living matter; what is this unit or atom of life: whether it is a man. an acorn, a micros oj.ic cell or the atom of radium, or something el.se that we know nothing of. In the realm of chemistry till eight years ago the chemist ruled supreme. To him the atom w;is the sacred structure. It was anathema to all who would divide it. Hut the physicist viewed it from a different standKint. In stead of looking down on it as the smallest of things, he liHkcd up to it as great compared with the smallest that he knew, and promised for it many xis.sibilities. In this .struggle he has lccn victorious, and the conquered territory, so to sjicak. the borderland tat ween the two sciences, has led us to form closer ties of friendship and a clearer under standing tat ween chemists and physicists alike. Why should it not ta s with the biologist? May it not ta tli.it a mutual understanding ct can ta arrived at with them, and that we yet may lecome allies in the same field: that the different cs that apparently exist should ta found to be due merely to some misapprehension or irrelevancy? Pasteur was a physicist and chemist, but he followed his studies where they led him with an ojen mind. Tnd.i!l was ala a physicist. In my own small way, I too jierhajis may ta permitted to pursue my experiments with freedom, wheresoever they may lead There are question in biology of the dee;est interest to the physicist. What I have obtained seemed in the first instance to have lcen cither mi-croK-s or crystals, or neither of these, but some thing in the tarder-Iine talwccn them and to mv mind they aptiear no.v to approximate more closely to bacteria than to trvstals as ordinarily tmder stiHHl. though strictlv sjHviking they apjear to differ largely from both, but I make this statement with all luc reserve. Until more twmcrful instruments, for which I am waiting at present, are at hand I should prefer to withhold further opinion; on this subject. The third possibility is at present the most prob able: that they are in the critical state of matter tatweon the mineral and the vegetable kingdoms. ossessing not all the qualities of either, but many of the properties of tatli: that unsteady or un stable state from which, for anything I know, or any of us can know, one process though probably not the only one by which the evolution of living matter from not living matter as we know these, may hav taken or ta taking place: that critical state, in a word, in which matter, through some hitherto unknown sourte of energy, may have sprung into life, or fallen into al solute inertness. For this I cannot offer at present, nor does it seem to me necessary to ofcr, any stronger arguments than those I have adduced already. And if it was pressed upon me at present to say whether these forms I have obtained are living or not living mat ter. I should ta" forced reluctant! to reply that they apjircd to me, from what I have dcscrilied, to ta in that anomalous condition like, for example, matter in the critical state tatween a liquid and a gas. That should satisfy cither of the devout ad herent of these oposite views. 1 should ta obliged to admit that for aught that I knew at present, they scented to convey to my mind and those of many others the tardcr-line tatween the living and the dead. Hut more than this I cannot say, and even this, it must ta tame in mind, is only a iitrson.il opinion, in which I tlo not feel confident th.it a worthier critic might not yet disclose a flaw. The "radium" may ta. and I am at prt-sent not loth to think is. that state of matter that separates, or ticrhaps unites, the organic and the inorganic worlds. Hut I prefer to give my own personal opinion merclv as a hint that in the radio-activity of matter ami the product produced by it in their growth, disintegration and decay mav ta sought Fditnr' Nnie: loha Butler Barkc ia a onnc man. in the prime nf life. He i an Irithmaa. and ent to Triaitr Collctc. Dufclia. hrn tutcca. Alter Ukiac hH decree, fce wred therewith Pn'ttnr Fitrgcrald in scientific research. Laarr he seat to Miua't Coilete. Blrtaiathatn. a a lecrarer. and ut-eauentiv earned a fcllonhin. in Oven't f!fill- Minchc:cr. He aeat treat Camhridre. and after vorkiac with lrofrMr Thoauoa lor aoautimc look a decree is mcarca three jrcartafo. that vital principle and source of vital energy which in the beginning withstood that high temperature at which most assuredly our planet must have once existed. Doubtless there was a time when it existed as an incandescent mass at a tcmjierature which life as we know it could not iossibly have withstood. As it cooled at some time or another life apiicarcd. That is our eiectation. Xfiw, if in sterilizing, as in the old exjerinients of thirty years ago, a test-tuta containing living matter the vital processes are destroyed, and do not apjicar again, how then, in the larger c.xiicrimcnt in the history of the earth, can the conditions of vital processes have originated? for the mere fact that it was at a higher temperature than tliat which could supjtort life was enough also, it would apjicar. to have eliminated all traces of what we call vitality. Still, as wc say, our cxjicctation is that in that larger e.x(ierimcnt which forms an obliterated jiage in 'he history of our planet, the most important phase in its development, life doubtless in a simple form did arise. The condi tions then must liave ta-en different from those existing in an ordinary sterilized tcst-tuta. as in the c.xjierimcnts of Pasteur. Tyndall and others. These e.xjieriments have really no taaring on the question at issue as to whether radio-activity can atford the energy for life. The process of radio-activity, however, is not destroyed by heat, at least not at teinju-mtures far higher than any at which life can lie maintained. This is the one new proerty of inorganic matter which has been discovered since the days of Iluxlev. and which endows it with Mime of the proierties of organic nature: of growth, of instability and of decay; and as we see now in the "radiota-s" of growth, of sul di vision and jiossibly of repro duction too. The problem of the origin of life, which the biologist for the time taing has almost, if not alto gether, abandoned, if not in des-air. at least in quiet resignation, would thus apjiear to present more hojK.ful signs of yielding a solution in the hands of the physicist than in his own. I say this with all ilue deferent e. New ideas and new met hotls of tackling the question are coming within our reach, while physical sciente is steadily stretching the tardcr-line of its territory jicrhajrs even into the greater world of living things. Hchind all these divisions anil sub-divisions of the sciences there are to ta found many assumptions, hyjiotheses wlikh for the time ta-ing may ta- and probably are extremely useful, although at the same time they should ta regarded as provisional, ami ought on no at count to ta- allowed to stand in the way of free siicculation and inquiry on the one hand, nor give support to gross assurance on the other. It will ta observed that our own views are not unlike those of the late Ilerlicrt Spencer, who talievcd that the continuity tatween animate anil inanimate matter v.. is a thing which in the course of time --though to him it was not evident when -would ta established on an exjierimental basis. And the late Professor Huxley, too. has eloquently expressed his own deep conviction on this all absorbing question, though to him it was an act of philosophic faith, a matter of exjicctation rather than of belief. He has well said these memorable word, which more than onte have lccn quoted and req noted, that With nnramc chemistry, molecular phy-ics and phy siology yet in their infancy and every "lay tnakin pro-