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The San Francisco Sunday Call. Magazine Section Part I. By Ruth.Berg — M — HIS new life saving crew; puts "I not forl!i to : sea In quest ot I wrecked humanity; neither Csis It brave the Itorrors ;of flame wrapped buildings- It iiwaits^ncitljer storm nor conflagration .• to- throw otit ( the life line, tut Instead, day by day; with infinite patience :'lt- j^or lives. Rale or shine, eojnnicf aßrrA-.'ti*-^ ter. those, tlrelsss; fighters /art yance eteafilly In - ..their * uncompromising straggle With' : . ''(fleaUi^Science.^ "whose gulfilng star Ehe^;llgh^tf/jr; the-rescu ers, has also provided ;thelr Cor the spirit of "exactitude and- truth, the epirlt of the microscope andi the teat tube dominates this entire station. It 1* the same Eplrit which' caused -tfte treat Pasteur to labor with unceasing hopefulness and T5T 5 ' 11 * 0^; enabled ; Itim finally to conquer many; of the worst diseases to which ' man Is heir. : This r. ew Etaiton, aJpionecr on tli i s coast. lls one of a .number scattered throughout -the til viiized' world;" Italy. Zinnia, Fraiice. < Madagascar,; and sonic Cozen other countries, each has 'its lab-, oratory for combating 1 the diseases wfcJcfajfor 6O many.^centuries have played fcavoo - with- human life. ' The Suited States 'has. not' been stow%4h realtxlnar the accompljshcO, and for a number, of years New -York land Chicago have had well equipped. In stitutes where thousands of patients are treated and " laboratorics^'wliero* enormous quantities sof life «;* saying) Ktnff Is prepared.' Hydropho'bia^riock^" jatr, bubonic pla&ue. serpent venom, and lastly,' but^most*lmppVtant,'^diph theria are In the lists* "of corniuejetj, foee. One by one theyHa^e \u25a0gcmgj&w&ri: before tli^unf altering .^iptcrmlgiaUan joi, the scientists. 'NoW.- ifc Is Jthat»*tlirs<i pioneers, appreciating' ; tile * moderation of Cai f fornla's ' cliujate j and ,*taklng^ ad--' vantage ' oC tJie /&erm--frec,,bfce2C3_ which K^vecp \u25a0In 'from the cold waters of tne 'broad^Paiclfic' have es-' lablislicd their, laboratory,,: on A " the 'cast-' crn shoro'ot SanFranciscO'bay.j \u2666.>-.-. In West Berkeley,* just : opposite ) the Golden Gate, 't)ie' 'separate if'white'ib'uild^ ings which iiouse the workers andltheir equipment look for all' the.w orld? likn pretty cottages, surrounded, as^they'are, with say, flowering* shrubs "and Vrccil kept paths. Closer. Investlsatlori'joC the premises reveals? that' awe* Inspiring ImmaculatVnrsK which one; can. llnd no where e!f<s except . In; hospital \u25a0\u25a0 operat ing roon«s." am] uiio ' slop inside^ the doors of any «'j£ " t!ie ; bulldings v is ' all that is n<H.-< i ssa''y«toconvinee'the, visitor that all things within- are docidcoly antiseptic' Tluj spotless ; walls *an'l floors, tlie'risrid ".exclusion of any orna-' mentation, the lack off odor, -which •we have come to know is the 'surest .'sign of cleanliness; "all these place where trained; bacteriologists diagnose and- investigate -'contagious and Infections diseases;, of malt r and animal. r -- • : -, .- A Model "Poison -Farm" - • The premises/are iargeiiandUhcjplan; of having:- eeparate. Isolated buildings lor each class of. work Is~followcd, thus eliminating any possible i risk* of ; con tamination. " The barns^ where "the : ani nials;uscd r for;tesiingspurposesrandlfor the manufacture bf^vaccinea and serums are « housed » are iat• a ; distance ;; from ° the main laboratory :^buildings^/'.Updn \en-\ terlns - the - stables^ where: the ] s horses \u25a0which furnish the-supply; of antitoxin 6erum are'; kepC one Is Immediately.' at-J tracted by* the large and • well stalls. \u25a0'',; The • general * health ,'of I thVi an I xnals is watched over; with the; greatest care and "each - horse \u25a0 Is I given; as ; much ftttpntinn as- is : the tnatlent^ in ; a-' sick wafd. To chi.ld; visitors! the .hordes of gruinca v pig 3 afford the. most interest and amusement. Eyery^shade and Viiapc: fc.r.cnrri "to" guinea piprJom sccrsis* to squirm -"around ' and alK*it within, \.lm Wired pens, ' appetites constantly,, dema'adiag-f j-esh supplies/ f Though : there, are .fa number of :dif- r £erent • scrums -tvnd; vaccines produced kV- the Cutter laboratory, the j~rca.te.st. space r and? attention* "has*; bciri gi vcri ;to diphtl:<?rla^ antitoxin. There are feV. to jwli'om : tlienam'e of itho^discase ',ls *'i: n-' XfsociatcdVwUh .dread,- "for \u25a0.'pidr; 'anil* s'ourif , ; - rich \u25a0 and '; poor,' . arc i afifeel' sus- 1 ceptfble to: lts ' infection! ''X'i^'-}} I^'/S^ ? .Probably^ls^a^yjry'.an-', •dent- disorder.'- Hirsch'refcris^to' a^dis-' .-which. Is .-spoken", of;in "the I Talmud Tand' in. the" Hippocratlc - cdilection;.;; Later Greek medical .writers inake^'mention ' »i. a throat ;aCfect!on*Trnlch , : .inay.;l»el <x\'A\ '.^? a . 11 * r /"5 : ?rV al ?*JV» ! CFS;*r*?<i I 'as ..diphtljrt rla. -3n medieval and rocent'times'thero are' numerous. accounts ' from -\u25a0[ nianyl P^rtsyof the*worl<J i'.'of epl'dcmic3 r of ,'iiia-' ll^"^ 1 sore throat," and there seems'-no' good '.reason : doubt' that imany j o£ 1 \u25a0 ihVse \u25a0were'epldemics of vi^ ' wasliiot,'- however,- until* tho* early, "part - of I the -'nlneteentk 7 century <± that tha true,*; specific .'character ;\6f ' fllphthcrla' 'was^recogmized • and 'established, ' 'niai lily; Jry^ the'labors. of -physiclaii; Bretqnneau^w-ho' published"jils' treatise in" 182r.*>The "bacillus"- associated - with; \u25a0the^lseaserwa's first dcfecrrDed'W^'lebs t inUBS2l'and,was Tirst cultLv'atcd •by-L.of^ * 'Iter^ )]*y§ ? *:, ' ",. Te !i 'y ea rt « hit £ r^thel;'s*e-.' rum" - r tfcatmcn t of diphtheria* was fln^ troduced. r; ""-. - - V-Zfr*? s ; vf ' * .v ~ : t J! ,s-'\ ,' t -»,-' -» ~ '\u25a0. \u25a0 - - '\u25a0 - -•'"." \u25a0'.':" No^Accident^l Discovery, *• , ',;" : John Fiske lias- said thatuhe Mllscbv-1 ol:y of Anieriea took a cenlufy~so'.tijati tiii ;disjcovVry ;of ,a npjiv treatment >'oZ Oilitit^rial^as hoi xi' uyAtt^rjoty&iic'.v liorfths alone, but was the crowning? re-' sult .vf B v\vurk which had been ' carried on in the laboratories for; over TO years., It'w^s not'^an accidental discove"ry,*l!k«: that; of' vaccination ,l>y Jenner, • but '.tlia 1 logical of .a Ion? series of ;6b-::; 6b- : : servations "and 'esperlments, all necesj sary- to ~the[ : fthal /result.- This was ac-' compllslied" through ;the labors of 'many; Independent'! workers, 'cm braci n g^somo : of jthe^ablest andUbcst trained • scientiflo raindsin*the :world. r :- '-'-^ :- f:l -'< \u25a0_'-'\u25a0 -^':'J: ,I arc practically, new \u25a0'agenjts',' for ' the^.cure -of ;_ germ"^ dis'eascs^'They ' were unkjiow.n-before^SSOi^wh^^Beh- ' rlngr, ' a - German,*, and tasato; fa* JiVp-* ajnyscr^wbrked^ou^.^u'elrXproduc^ipiii'^. Since. <the,n.;se yeraKGcrman i andiFf encix; bacterioloslsis *• en larked -.upon 'itheTwofltf* of Tth"cic j i>ioncers! nii^c nl>out" flveTvears' later, aftccranumrrienfo amount t of, lab-, boratoVK exjtcrinientation; a-/few^ anti-. ;toxinfe;wcrc^pcff«cted,"!. the.inoFtlimßor-^ (taht; of which is^'diplUheria antitoxi hr- For.'the 'itpastV f ew, years ,'Arilcrican '.'< and' , European 'laboratories. :.foll6wins7,the< methods "of \u2666 these workers.} have; been' able : to'; pfoduce'.'d tp'hthcrta' a"nti tox In in •; its * highest;-, potenej-.; " The \u25a0\u25a0- method^Sof; production is\ simple. \u25a0_ yet requires -the c most carefui' attention to Octails:' lt!i-i : nothing but .the 'serum of. hordes' * bloods contain|nff.a/Fpb"tauee which, wlll{ncu-; tf aline oil^irotcctaKCiinstilher'oi^oir or" toxin? m-ifjiliic^d'.ltyVthe id lphllieria Kcr'm.' It is nut; a- lncdichie- in v an.v.-i ; cnstt;;<»f \u25a0 \u25a0 •-.?'\u25a0 \u0084<. ,- ;. . . . - .- %.\u25a0 *\u25a0._' ; ».\u25a0\u25a0-.• \u0084._.y \u25a0 v-" j^ the \u25a0 wor«i and- there* is>no secrecy s in* itsf prcdHcUon'. ' :. / '\ " 1 • ' '{ **Tol YrliUe' diphtheria' a"ntitoxinHiti?is} ->-.- i.v.-..» i.-i.'o- -..?„» -..\u25a0«.v.-r*.«.---r.v-!t^..v r.;j \u25a0-<•\u25a0> \u0084-J first. neccssaryl to tecure: ai pure* culture ' of^ the; diphtheria s ; germ." ' S.uch^culture \ may : be r made,ffom % ; the. throat of a per-* \u25a0Boht^rck*rwltht'ttie>dlselLse'*^or^lmay^be] obtained . from somo; American or ifoV;]: eig^n laboratory/making; antitoxin. 'XJTJie% next EtepMs'to; produce Borne diphtheria^ toxin, whiAt Ms produced by. growlns'l SAN FRANCISCO prepared^tecf.* tea" or boulHonlfnfsult .nbltj; flasks. /.This bouillon lsicultc^lik* -that made Vat* horn» 'or served r lti : res- ; taurantc: |^ \ s'mall^quantltyr*«if v the' ' germs 'is* deposited* on* ". .'the? surfaceijLof 1 ;tne f SbpuJuion Jand<ithe flasks are.put^inv on-incubatbr/VhichVis-kcpt^uriifolrrnly.' at tho ite^mpcraturejof th« : human^bod>\i; In} a A'dV^o^'t^^.t^eJ^nU^^i^aw^is}' ; coycfed*by 4 4ttie-i multiplied.^growth vote , ; ithe'i germs? and ? byjihe fend *of * a Vweeic"? lit! has I become [al thick .white; 1 tenacious I mombranelike:, growth.. This .surfaoet ls" : r exactly -like' ''tho ;whito: 'or n " in*- tlie : throat fof^ 1 aj, person';^ick/.3vllJ^^ilpHt^^^ss^^^Mu| other, words, we have: a- <ty pi carcase toff ;tru«dlpbtherla"in eacli flask.' The igefiwsf ! •WWI93 groTirlng * on ? tho , ot." $ho? .-,-. : ,w,. >--.i . .--\u25a0;• \u0084 , v . f-vi>*^. *-y \u25a0 r;'.-.-' »:.•\u25a0\u25a0.\u25a0.\u25a0\u25a0 \u25a0.'\u25a0-J-, i?-i, .A'--. boutllonitake it'in as a fopd,and? secrctai ;productsLth*t;are'poi9ondus.i.ThejbounxJ ;-lon ,;>bcco!iics inore \u25a0•\u25a0*©r *\u25a0• Iftss -\u25a0 saturated \u25a0 \u25a0;with these poisonsjand 'this igpnlutu^sl i the so-called- dlphthcriaAoxin»*Aji iex^T \u25a0actly^ similar spro<ses3^,takeBl*placellnl Uhelthroat of 'a'personf slcfclwithfdipli^ ; theria. sThe \ germ»,multlplles,iprodu<»Jlj whitish*patcheaio»|thejs«irfaceiOfsthe* f throat and > sot? produces g a <*; toxin or f ; poison >,whlch"ilBTabBorbed^ Into \u25a0 ; the; sys^k afters having/, been ?inaae*lsr,usedltolin-l \u0084the I antifj;